Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife.

ABSTRACT:

Objectives

The development of Type 1 diabetes mellitus (T1DM) within the first 7 years of life has been linked to poorer cognitive performance. Adults with T1DM have altered functional brain connectivity, but no studies have examined whether earlier age of T1DM onset is associated with functional connectivity later in life. Accordingly, we tested the relationship between age of onset and resting state functional connectivity in a cohort of middle-aged adults with childhood-onset T1DM.

Methods

Participants were from a subsample of the Pittsburgh Epidemiology of Diabetes Complications cohort and included 66 adults (mean age = 47.54 years, 32 men). Resting state blood oxygen level-dependent activity was used to calculate mean connectivity for eight functional brain networks. A

SUBMITTER: Ryan JP 

PROVIDER: S-EPMC4503367 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature