Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population.

ABSTRACT:

Background

The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China.

Methods<

SUBMITTER: Dong Y 

PROVIDER: S-EPMC4503434 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature