Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology.

ABSTRACT:

Background

Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation to stress exposure.

Methods

Two-hundred ninety healthy adults provided information on childhood parental loss and maltreatment and completed diagnostic interviews. Participants were categorized into four groups based upon the presence or absence of childhood adversity and the presence or absence of lifetime psychopathology (depressive, anxiety, and substance use diso

SUBMITTER: Tyrka AR 

PROVIDER: S-EPMC4503518 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature