Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.

ABSTRACT:

Objective

Evidence suggests protective effects of vitamin D and antitumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25-dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse association between vitamin D and colorectal cancer risk might be stronger for cancers with high-level immune response than those with low-level immune response.

Design

We designed a nested case-control study (318 rectal and colon carcinoma cases and 624 matched controls) within the Nurses' Health Study and Health Professionals Follow-up Study using molecular pathological epidemiology database. Multivariable conditional logist

SUBMITTER: Song M 

PROVIDER: S-EPMC4503524 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature