TFIIS-Dependent Non-coding Transcription Regulates Developmental Genome Rearrangements.

ABSTRACT: Because of their nuclear dimorphism, ciliates provide a unique opportunity to study the role of non-coding RNAs (ncRNAs) in the communication between germline and somatic lineages. In these unicellular eukaryotes, a new somatic nucleus develops at each sexual cycle from a copy of the zygotic (germline) nucleus, while the old somatic nucleus degenerates. In the ciliate Paramecium tetraurelia, the genome is massively rearranged during this process through the reproducible elimination of repeated sequences and the precise excision of over 45,000 short, single-copy Internal Eliminated Sequences (IESs). Different types of ncRNAs resulting from genome-wide transcription were shown to be involved in the epigenetic regulation of genome rearrangements. To understand how ncRNAs are produced from the

SUBMITTER: Maliszewska-Olejniczak K 

PROVIDER: S-EPMC4503560 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature