Tandem Duplications and the Limits of Natural Selection in Drosophila yakuba and Drosophila simulans.

ABSTRACT: Tandem duplications are an essential source of genetic novelty, and their variation in natural populations is expected to influence adaptive walks. Here, we describe evolutionary impacts of recently-derived, segregating tandem duplications in Drosophila yakuba and Drosophila simulans. We observe an excess of duplicated genes involved in defense against pathogens, insecticide resistance, chorion development, cuticular peptides, and lipases or endopeptidases associated with the accessory glands across both species. The observed agreement is greater than expectations on chance alone, suggesting large amounts of convergence across functional categories. We document evidence of widespread selection on the D. simulans X, suggesting adaptation through duplication is common on the X. Despite the e

SUBMITTER: Rogers RL 

PROVIDER: S-EPMC4503668 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature