Association between MEFV Mutations M694V and M680I and Behcet's Disease: A Meta-Analysis.

ABSTRACT:

Objective

Several studies have identified an association between Behçet's disease (BD) and mutations in the Mediterranean fever (MEFV) gene, which was originally linked to the autosomal recessive disease, Familial Mediterranean fever. However, no consensus has been reached. Here, a meta-analysis was conducted on published data to comprehensively evaluate this relationship.

Methods

Literature searches were performed in Pubmed, Embase, the Web of Science, and HuGE Navigator databases, in order to identify studies pertaining to the association between MEFV mutations and BD. Two investigators independently extracted and evaluated the data from eligible studies. The association between MEFV mutations (M694V, M680I, and E148Q) and BD was estimated overall by the odds ratio (OR) an

SUBMITTER: Wu Z 

PROVIDER: S-EPMC4503748 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature