Nonrandom Distribution of miRNAs Genes and Single Nucleotide Variants in Keratoconus Loci.

ABSTRACT: Despite numerous studies, the causes of both development and progression of keratoconus remain elusive. Previous studies of this disorder focused mainly on one or two genetic factors only. However, in the analysis of such complex diseases all potential factors should be taken into consideration. The purpose of this study was a comprehensive analysis of known keratoconus loci to uncover genetic factors involved in this disease causation in the general population, which could be omitted in the original studies. In this investigation genomic data available in various databases and experimental own data were assessed. The lists of single nucleotide variants and miRNA genes localized in reported keratoconus loci were obtained from Ensembl and miRBase, respectively. The potential impact of nonsy

SUBMITTER: Nowak DM 

PROVIDER: S-EPMC4503774 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature