Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies.

ABSTRACT: Behaviors and underlying brain circuits show characteristic changes across the lifespan that produce sensitive windows of vulnerability and resilience to psychopathology. Understanding the developmental course of these changes may inform which treatments are best at what ages. Focusing on behavioral domains and neurobiological substrates conserved from mouse to human supports reciprocal hypothesis generation and testing that leverages the strengths of each system in understanding their development. Introducing human genetic variants into mice can further define effects of individual variation on normative development, how they contribute to risk and resilience for mental illness, and inform personalized treatment opportunities. This article emphasizes the period of adolescence, when there

SUBMITTER: Casey BJ 

PROVIDER: S-EPMC4503788 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature