Pathogenesis and mechanisms of antibody-mediated hemolysis.

ABSTRACT:

Background

The clinical consequences of antibodies to red blood cells (RBCs) have been studied for a century. Most clinically relevant antibodies can be detected by sensitive in vitro assays. Several mechanisms of antibody-mediated hemolysis are well understood. Such hemolysis after transfusion is reliably avoided in a donor-recipient pair, if one individual is negative for the cognate antigen to which the other has the antibody.

Study design and results

Mechanisms of antibody-mediated hemolysis were reviewed based on a presentation at the Strategies to Address Hemolytic Complications of Immune Globulin Infusions Workshop addressing intravenous immunoglobulin (IVIG) and ABO antibodies. The presented topics included the rates of intravascular and extravascular hemolysis; immu

SUBMITTER: Flegel WA 

PROVIDER: S-EPMC4503931 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature