The use of polyoxometalates in protein crystallography - An attempt to widen a well-known bottleneck.

ABSTRACT: Polyoxometalates (POMs) are discrete polynuclear metal-oxo anions with a fascinating variety of structures and unique chemical and physical properties. Their application in various fields is well covered in the literature, however little information about their usage in protein crystallization is available. This review summarizes the impact of the vast class of POMs on the formation of protein crystals, a well-known (frustrating) bottleneck in macromolecular crystallography, with the associated structure elucidation and a particular emphasis focused on POM's potential as a powerful crystallization additive for future research. The Protein Data Bank (PDB) was scanned for protein structures with incorporated POMs which were assigned a PDB ligand ID resulting in 30 PDB entries. These structur

SUBMITTER: Bijelic A 

PROVIDER: S-EPMC4504029 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature