Identification and pathogenicity of a variant porcine epidemic diarrhea virus field strain with reduced virulence.

ABSTRACT:

Background

Since 2010, a variant Porcine epidemic diarrhea virus (PEDV), which causes an acute, highly contagious, and devastating viral enteric disease with a high mortality rate in suckling pigs, broke out in China and spread rapidly to neighboring countries, even to the North America. This virus gradually became the main subtype of PEDV worldwide. However, there were no reports of mild pathogenicity of a variant porcine epidemic diarrhea virus in China.

Findings

In 2013, a PEDV-positive sample from a sow with very mild clinical sign was used to inoculate in Vero cells to isolate the virus. This PEDV field strain, designated FL2013 strain, was successfully propagated and genetically characterized. The phylogenetic trees based upon either the complete genome or S gene showe

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4504071 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature