Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling.

ABSTRACT: The steroid receptor-associated immunophilins FKBP51, FKBP52, CyP40 and PP5 have specific roles in steroid receptor function that impact steroid hormone-binding affinity, nucleocytoplasmic shuttling and transcriptional activation of target genes in a tissue-specific manner. Aberrant expression of these functionally unique immunophilins has the potential to cause steroid-based diseases, including breast and prostate cancer, diabetes and related metabolic disorders, male and female infertility and major depressive disorders. This review addresses the function of these proteins as co-chaperones in steroid receptor-Hsp90 complexes and extensively covers current knowledge of the link between the steroid receptor-associated immunophilins and human disease. An improved understanding of their mech

SUBMITTER: Ratajczak T 

PROVIDER: S-EPMC4504154 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature