Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most frequent and aggressive type of adult brain tumor. Most GBMs express telomerase; a high level of intra-tumoral telomerase activity (TA) is predictive of poor prognosis. Thus, telomerase inhibitors are promising options to treat GBM. These inhibitors increase the response to radiotherapy (RT), in vitro as well as in vivo. Since typical treatments for GBM include RT, our objective was to evaluate the efficiency of Imetelstat (TA inhibitor) combined with RT.

Findings

We used a murine orthotopic model of human GBM (N = 8 to11 mice per group) and μMRI imaging to evaluate the efficacy of Imetelstat (delivered by intra-peritoneal injection) alone and combined with RT. Using a clinically established protocol, we demonstrated that Imetelstat

SUBMITTER: Ferrandon S 

PROVIDER: S-EPMC4504179 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature