A potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer.

ABSTRACT:

Background

Accumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis of cancer, indicating the potential utility of lncRNAs as cancer prognostic or diagnostic markers. However, the power of lncRNA signatures in predicting the survival of patients with non-small cell lung cancer (NSCLC) has not yet been investigated.

Methods

We performed an array-based transcriptional analysis of lncRNAs in large patient cohorts with NSCLC by repurposing microarray probes from the gene expression omnibus database. A risk score model was constructed based on the expression data of these eight lncRNAs in the training dataset of NSCLC patients and was subsequently validated in other two independent NSCLC d

SUBMITTER: Zhou M 

PROVIDER: S-EPMC4504221 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature