Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections.

ABSTRACT: The construction of spinal sensory-motor circuits involves the selection of appropriate synaptic partners and the allocation of precise synaptic input densities. Many aspects of spinal sensory-motor selectivity appear to be preserved when peripheral sensory activation is blocked, which has led to a view that sensory-motor circuits are assembled in an activity-independent manner. Yet it remains unclear whether activity-dependent refinement has a role in the establishment of connections between sensory afferents and those motor pools that have synergistic biomechanical functions. We show here that genetically abolishing central sensory-motor neurotransmission leads to a selective enhancement in the number and density of such "heteronymous" connections, whereas other aspects of sensory-motor

SUBMITTER: Mendelsohn AI 

PROVIDER: S-EPMC4504246 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature