Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee.

ABSTRACT:

Background

Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from dif

SUBMITTER: Gonzalez-Alvarez R 

PROVIDER: S-EPMC4504400 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature