Identification of lncRNA expression profile in the spinal cord of mice following spinal nerve ligation-induced neuropathic pain.

ABSTRACT:

Background

Neuropathic pain that caused by lesion or dysfunction of the nervous system is associated with gene expression changes in the sensory pathway. Long noncoding RNAs (lncRNAs) have been reported to be able to regulate gene expression. Identifying lncRNA expression patterns in the spinal cord under normal and neuropathic pain conditions is essential for understanding the genetic mechanisms behind the pathogenesis of neuropathic pain.

Results

Spinal nerve ligation (SNL) induced rapid and persistent pain hypersensitivity, characterized by mechanical allodynia and heat hyperalgesia. Meanwhile, astrocytes and microglia were dramatically activated in the ipsilateral spinal cord dorsal horn at 10 days after SNL. Further lncRNA microarray and mRNA microarray analysis showed

SUBMITTER: Jiang BC 

PROVIDER: S-EPMC4504460 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature