Reassessment of Iron Biomarkers for Prediction of Dialysis Iron Overload: An MRI Study.

ABSTRACT:

Background and objectives

Iron overload among hemodialysis patients was previously considered rare but is now an increasingly recognized clinical situation. We analyzed correlations between iron biomarkers and the liver iron concentration (LIC) measured by magnetic resonance imaging (MRI), and examined their diagnostic accuracy for iron overload.

Design, setting, participants and measurements

We performed a prospective cross-sectional study from 31 January 2005 to 31 August 2013 in the dialysis centre of a French community-based private hospital. A cohort of 212 hemodialysis patients free of overt inflammation or malnutrition, were treated for anemia with parenteral iron-sucrose and an erythropoesis-stimulating agent, in keeping with current clinical guidelines. Blinded meas

SUBMITTER: Rostoker G 

PROVIDER: S-EPMC4504469 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature