Macrophages Subvert Adaptive Immunity to Urinary Tract Infection.

ABSTRACT: Urinary tract infection (UTI) is one of the most common bacterial infections with frequent recurrence being a major medical challenge. Development of effective therapies has been impeded by the lack of knowledge of events leading to adaptive immunity. Here, we establish conclusive evidence that an adaptive immune response is generated during UTI, yet this response does not establish sterilizing immunity. To investigate the underlying deficiency, we delineated the naïve bladder immune cell compartment, identifying resident macrophages as the most populous immune cell. To evaluate their impact on the establishment of adaptive immune responses following infection, we measured bacterial clearance in mice depleted of either circulating monocytes, which give rise to macrophages, or bladder resid

SUBMITTER: Mora-Bau G 

PROVIDER: S-EPMC4504509 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature