Genetic risk factors affecting mitochondrial function are associated with kidney disease in people with Type 1 diabetes.

ABSTRACT:

Aim

To evaluate the association with diabetic kidney disease of single nucleotide polymorphisms (SNPs) that may contribute to mitochondrial dysfunction.

Methods

The mitochondrial genome and 1039 nuclear genes that are integral to mitochondrial function were investigated using a case (n = 823 individuals with diabetic kidney disease) vs. control (n = 903 individuals with diabetes and no renal disease) approach. All people included in the analysis were of white European origin and were diagnosed with Type 1 diabetes before the age of 31 years. Replication was conducted in 5093 people with similar phenotypes to those of the discovery collection. Association analyses were performed using the plink genetic analysis toolset, with adjustment for relevant covariates.

Results

SUBMITTER: Swan EJ 

PROVIDER: S-EPMC4504747 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature