Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations.

ABSTRACT:

Rationale

Researchers studying behavioral and physiologic effects of d-amphetamine have explored individual response differences to the drug. Concurrently, genome-wide analyses have identified several single-nucleotide polymorphisms (SNPs) associated with these traits. Univariate methods can identify SNPs associated with behavioral and physiological traits, but multivariate analyses allow identification of clusters of related biologically relevant SNPs and behavioral components.

Objectives

The aim of the study was to identify clusters of related biologically relevant SNPs and behavioral components in the responses of healthy individuals to d-amphetamine using multivariate analysis.

Methods

Individuals (N = 375) without substance abuse histories completed surveys and d

SUBMITTER: Yarosh HL 

PROVIDER: S-EPMC4504822 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature