Analysis of Association between Norepinephrine Transporter Gene Polymorphisms and Personality Traits of NEO-FFI in a Japanese Population.

ABSTRACT:

Objective

Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). According to Cloninger's theory, the noradrenergic system mediates the personality trait of reward dependence. Thus far, although association studies on NET gene polymorphisms and Cloninger's personality traits have been reported, they yielded inconsistent results. Therefore, in the present study we investigated whether or not the 1287G/A, -182T/C and -3081A/T polymorphisms of the NET gene (SLC6A2) are associated with reward dependence-related traits, as assessed by the five-factor model.

Methods

After written informed consent was obtained from participants, the three NET gene polymorphisms were analyzed by poly

SUBMITTER: Narita S 

PROVIDER: S-EPMC4504922 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature