Microarray Analysis of the Major Depressive Disorder mRNA Profile Data.

ABSTRACT:

Objective

Major depressive disorder (MDD) is a common mood disorder associated with several psychophysiological changes like disturbances of sleep, appetite, or sexual desire, and it affects the patients' life seriously. We aimed to explore a genetic method to investigate the mechanism of MDD.

Methods

The mRNA expression profile (GSE53987) of MDD was downloaded from Gene Expression Omnibus database, including 105 samples of three brain regions in post-mortem tissue suffered from MDD and unaffected controls. Differentially expressed genes (DEGs) in MDD were identified using the Limma package in R. Gene Ontology functions and Kyoto Enrichment of Genes and Genomes pathways of the selected DEGs were enriched using Database for Annotation, Visualization and Integrated Discovery.

SUBMITTER: Gao L 

PROVIDER: S-EPMC4504923 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature