Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging.

ABSTRACT: The aging process of skin has been investigated recently with respect to mitochondrial function and oxidative stress. We have here observed striking phenotypic and clinical similarity between skin aging and recessive dystrophic Epidermolysis bullosa (RDEB), which is caused by recessive mutations in the gene coding for collagen VII,COL7A1. Ultrastructural changes, defects in wound healing, and inflammation markers are in part shared with aged skin. We have here compared the skin transcriptomes of young adults suffering from RDEB with that of sex- and age-matched healthy probands. In parallel we have compared the skin transcriptome of healthy young adults with that of elderly healthy donors. Quite surprisingly, there was a large overlap of the two gene lists that concerned a limited number o

SUBMITTER: Breitenbach JS 

PROVIDER: S-EPMC4505166 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature