In Vivo Efficacy of Antimicrobials against Biofilm-Producing Pseudomonas aeruginosa.

ABSTRACT: Patients suffering from cystic fibrosis (CF) are commonly affected by chronic Pseudomonas aeruginosa biofilm infections. This is the main cause for the high disease severity. In this study, we demonstrate that P. aeruginosa is able to efficiently colonize murine solid tumors after intravenous injection and to form biofilms in this tissue. Biofilm formation was evident by electron microscopy. Such structures could not be observed with transposon mutants, which were defective in biofilm formation. Comparative transcriptional profiling of P. aeruginosa indicated physiological similarity of the bacteria in the murine tumor model and the CF lung. The efficacy of currently available antibiotics for treatment of P. aeruginosa-infected CF lungs, such as ciprofloxacin, colistin, and tobramycin, cou

SUBMITTER: Pawar V 

PROVIDER: S-EPMC4505208 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature