Ontology highlight
ABSTRACT:
SUBMITTER: Song W
PROVIDER: S-EPMC4505541 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Song Wenjun W Cho Yongcheol Y Watt Dana D Cavalli Valeria V
The Journal of biological chemistry 20150424 23
Injured peripheral neurons successfully activate a pro-regenerative program to enable axon regeneration and functional recovery. The microtubule-dependent retrograde transport of injury signals from the lesion site in the axon back to the cell soma stimulates the increased growth capacity of injured neurons. However, the mechanisms initiating this retrograde transport remain poorly understood. Here we show that tubulin-tyrosine ligase (TTL) is required to increase the levels of tyrosinated α-tub ...[more]