Bioinformatics perspective on rhomboid intramembrane protease evolution and function.

ABSTRACT: Endopeptidase classification based on catalytic mechanism and evolutionary history has proven to be invaluable to the study of proteolytic enzymes. Such general mechanistic- and evolutionary- based groupings have launched experimental investigations, because knowledge gained for one family member tends to apply to the other closely related enzymes. The serine endopeptidases represent one of the most abundant and diverse groups, with their apparently successful proteolytic mechanism having arisen independently many times throughout evolution, giving rise to the well-studied soluble chemotrypsins and subtilisins, among many others. A large and diverse family of polytopic transmembrane proteins known as rhomboids has also evolved the serine protease mechanism. While the spatial structure, mec

SUBMITTER: Kinch LN 

PROVIDER: S-EPMC4505743 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature