Fronto-parietal and cingulo-opercular network integrity and cognition in health and schizophrenia.

ABSTRACT: Growing evidence suggests that coordinated activity within specific functional brain networks supports cognitive ability, and that abnormalities in brain connectivity may underlie cognitive deficits observed in neuropsychiatric diseases, such as schizophrenia. Two functional networks, the fronto-parietal network (FPN) and cingulo-opercular network (CON), are hypothesized to support top-down control of executive functioning, and have therefore emerged as potential drivers of cognitive impairment in disease-states. Graph theoretic analyses of functional connectivity data can characterize network topology, allowing the relationships between cognitive ability and network integrity to be examined. In the current study we applied graph analysis to pseudo-resting state data in 54 healthy subjects

SUBMITTER: Sheffield JM 

PROVIDER: S-EPMC4505838 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature