Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z.

ABSTRACT:

Background

AGN 201904-Z is a new, slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time.

Aim

To investigate pharmacodynamics and pharmacokinetics of AGN 201904-Z compared to esomeprazole.

Methods

A randomized, open-label, parallel group, investigator-blinded intragastric pH study was conducted in 24 healthy Helicobacter pylori negative male volunteers. AGN 201904-Z enteric-coated capsules (600 mg/day) or esomeprazole delayed-release tablets (40 mg/day) were administered for 5 days. Twenty-four-hour intragastric pH recordings were acquired at baseline, days 1, 3 and 5 with blood levels of omeprazole, AGN 201904-Z and gastrin.

Results

On day 1, median nocturna

SUBMITTER: Hunt RH 

PROVIDER: S-EPMC4505925 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature