Mapping of the Sequences Directing Localization of the Drosophila Germ Cell-Expressed Protein (GCE).

ABSTRACT: Drosophila melanogaster germ cell-expressed protein (GCE) belongs to the family of bHLH-PAS transcription factors that are the regulators of gene expression networks that determine many physiological and developmental processes. GCE is a homolog of D. melanogaster methoprene tolerant protein (MET), a key mediator of anti-metamorphic signaling in insects and the putative juvenile hormone receptor. Recently, it has been shown that the functions of MET and GCE are only partially redundant and tissue specific. The ability of bHLH-PAS proteins to fulfill their function depends on proper intracellular trafficking, determined by specific sequences, i.e. the nuclear localization signal (NLS) and the nuclear export signal (NES). Nevertheless, until now no data has been published on the GCE intracel

SUBMITTER: Greb-Markiewicz B 

PROVIDER: S-EPMC4505938 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature