Reduced dynamic hyperinflation after LVRS is associated with improved exercise tolerance.

ABSTRACT:

Introduction

Dynamic hyperinflation (DH) after lung volume reduction surgery (LVRS) has not been well studied. It is not known if reductions in DH correlate with improvements in exercise performance post-LVRS.

Methods

Forty-two upper-lobe predominant emphysema patients who underwent LVRS were analyzed. Inspiratory capacity was measured every 2 min during symptom-limited cardiopulmonary exercise test (CPET) and end-expiratory lung volumes (EELV) were calculated. The main measure of DH was EELV/TLC ratio matched at metabolic isotimes (based on the post-rehabilitation VCO2max).

Results

Patients had very severe airflow obstruction (FEV1 28.3 ± 7.0% predicted), were hyperinflated (TLC 125 ± 17% predicted) and gas trapped (RV 198 ± 39% predicted). Compared to the post-rehab

SUBMITTER: Lammi MR 

PROVIDER: S-EPMC4505940 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature