Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration.

ABSTRACT:

Objective

The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MS patients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T).

Methods

17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) disease duration underwent 7 T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images.

Results

126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration

SUBMITTER: Bozin I 

PROVIDER: S-EPMC4506094 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature