Genetic Modulation of Neurocognitive Function in Glioma Patients.

ABSTRACT:

Purpose

Accumulating evidence supports the contention that genetic variation is associated with neurocognitive function in healthy individuals and increased risk for neurocognitive decline in a variety of patient populations, including cancer patients. However, this has rarely been studied in glioma patients.

Experimental design

To identify the effect of genetic variants on neurocognitive function, we examined the relationship between the genotype frequencies of 10,967 single-nucleotide polymorphisms in 580 genes related to five pathways (inflammation, DNA repair, metabolism, cognitive, and telomerase) and neurocognitive function in 233 newly diagnosed glioma patients before surgical resection. Four neuropsychologic tests that measured memory (Hopkins Verbal Learning Test-Re

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4506227 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature