Surrogate markers for time-varying treatments and outcomes.

ABSTRACT:

Background

A surrogate marker is a variable commonly used in clinical trials to guide treatment decisions when the outcome of ultimate interest is not available. A good surrogate marker is one where the treatment effect on the surrogate is a strong predictor of the effect of treatment on the outcome. We review the situation when there is one treatment delivered at baseline, one surrogate measured at one later time point, and one ultimate outcome of interest and discuss new issues arising when variables are time-varying.

Methods

Most of the literature on surrogate markers has only considered simple settings with one treatment, one surrogate, and one outcome of interest at a fixed time point. However, more complicated time-varying settings are common in practice. In this artic

SUBMITTER: Hsu JY 

PROVIDER: S-EPMC4506229 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature