Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior.

ABSTRACT: The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetically defined cell types in the dorsomedial PFC of mice performing a PFC-dependent sensory discrimination task. We found that inhibitory interneurons of the same subtype were similar to each other, but different subtypes preferentially signaled different task-related events: somatostatin-positive neurons primarily signaled motor action (licking), vasoactive intestinal peptide-positive neurons responded strongly to action outcomes, whereas parvalbumin-positive neurons were less s

SUBMITTER: Pinto L 

PROVIDER: S-EPMC4506259 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature