Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells.

ABSTRACT: The development of in vitro molecular biomarkers to accurately predict toxicological effects has become a priority to advance testing strategies for human health risk assessment. The application of in vitro transcriptomic biomarkers promises increased throughput as well as a reduction in animal use. However, the existing protocols for predictive transcriptional signatures do not establish appropriate guidelines for dose selection or account for the fact that toxic agents may have pleiotropic effects. Therefore, comparison of transcriptome profiles across agents and studies has been difficult. Here we present a dataset of transcriptional profiles for TK6 cells exposed to a battery of well-characterized genotoxic and nongenotoxic chemicals. The experimental conditions applied a new dose opti

SUBMITTER: Li HH 

PROVIDER: S-EPMC4506269 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature