Post-transplant survival is improved for hepatitis C recipients who are RNA negative at time of liver transplantation.

ABSTRACT:

Unlabelled

Hepatitis C virus (HCV) infection recurs universally in patients who are viremic at liver transplantation and likely accounts for the diminished post-transplant graft and patient survival. We evaluated whether undetectable HCV RNA pretransplant improves graft and patient survival after transplantation. Cases, defined by HCV listing diagnosis and positive HCV antibody, were selected from the Scientific Registry of Transplant Recipients database and further grouped as HCV RNA-positive (n = 4978) or negative (n = 445) based upon pretransplant testing. Controls were non-HCV recipients (n = 2995). RNA-negative cases had significantly better 5-year graft (72% vs. 64%) and patient (79% vs. 69%) survival than RNA-positive cases (P < 0.01 for both), and similar survival as contro

SUBMITTER: Fortune BE 

PROVIDER: S-EPMC4506275 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature