Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.

ABSTRACT:

Background

The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems.

Methods

We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted for mortality risk in 3,140 individuals selected for familial longevity from the Long Life Family Study. The genome-wide association study used the Long Life Family Study as the discovery cohort and individuals from the Cardiovascular Health Study and the Framingham Heart Study as replication cohorts.

Results

There were no genome-wide significant findings from the genome-wide association study; however, several single-nucleotide polymorphisms near ZNF704 on chromosome 8q21.13 wer

SUBMITTER: Minster RL 

PROVIDER: S-EPMC4506316 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature