The impact of development and sensory deprivation on dendritic protrusions in the mouse barrel cortex.

ABSTRACT: Dendritic protrusions (spines and filopodia) are structural indicators of synapses that have been linked to neuronal learning and memory through their morphological alterations induced by development and experienced-dependent activities. Although previous studies have demonstrated that depriving sensory experience leads to structural changes in neocortical organization, the more subtle effects on dendritic protrusions remain unclear, mostly due to focus on only one specific cell type and/or age of manipulation. Here, we show that sensory deprivation induced by whisker trimming influences the dendritic protrusions of basilar dendrites located in thalamocortical recipient lamina (IV and VI) of the mouse barrel cortex in a layer-specific manner. Following 1 month of whisker trimming after bir

SUBMITTER: Chen CC 

PROVIDER: S-EPMC4506326 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature