Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival.

ABSTRACT:

Background

Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. This study determined the prognostic significance of preoperative neutrophil:lymphocyte (NLR), platelet:lymphocyte (PLR) and monocyte:lymphocyte (MLR) ratios in endometrial cancer.

Methods

Clinicopathological and 5-year follow-up data were obtained for a retrospective series of surgically treated endometrial cancer patients (n=605). Prognostic significance was determined for overall (OS) and cancer-specific survival (CSS) using Cox proportional hazards models and Kaplan-Meier analysis. Receiver-operator characteristic and log-rank functions were used to optimise cut-offs. NLR, PLR and MLR associations with clinicopathological va

SUBMITTER: Cummings M 

PROVIDER: S-EPMC4506386 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature