Dual inhibition of survivin and MAOA synergistically impairs growth of PTEN-negative prostate cancer.

ABSTRACT:

Background

Survivin and monoamine oxidase A (MAOA) levels are elevated in prostate cancer (PCa) compared to normal prostate glands. However, the relationship between survivin and MAOA in PCa is unclear.

Methods

We examined MAOA expression in the prostate lobes of a conditional PTEN-deficient mouse model mirroring human PCa, with or without survivin knockout. We also silenced one gene at a time and examined the expression of the other. We further evaluated the combination of MAOA inhibitors and survivin suppressants on the growth, viability, migration and invasion of PCa cells.

Results

Survivin and MAOA levels are both increased in clinical PCa tissues and significantly associated with patients' survival. Survivin depletion delayed MAOA increase during PCa progression,

SUBMITTER: Xu S 

PROVIDER: S-EPMC4506394 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature