MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project.

ABSTRACT:

Background

The melanocortin-1-receptor (MC1R) gene regulates human pigmentation and is highly polymorphic in populations of European origins. The aims of this study were to evaluate the association between MC1R variants and the risk of non-melanoma skin cancer (NMSC), and to investigate whether risk estimates differed by phenotypic characteristics.

Methods

Data on 3527 NMSC cases and 9391 controls were gathered through the M-SKIP Project, an international pooled-analysis on MC1R, skin cancer and phenotypic characteristics. We calculated summary odds ratios (SOR) with random-effect models, and performed stratified analyses.

Results

Subjects carrying at least one MC1R variant had an increased risk of NMSC overall, basal cell carcinoma (BCC) and squamous cell carcinoma (

SUBMITTER: Tagliabue E 

PROVIDER: S-EPMC4506395 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature