Systemic neutrophil-to-lymphocyte ratio in colorectal cancer: the relationship to patient survival, tumour biology and local lymphocytic response to tumour.

ABSTRACT:

Background

Colorectal cancer (CRC) is a major cause of mortality and morbidity. The impact of inflammatory biomarkers (C-reactive protein etc.) on CRC is increasingly studied including systemic neutrophil-to-lymphocyte ratio (NLR) as they seem to predict outcome.

Methods

All patients who underwent curative resection for CRC from 2000 to 2004 at Leeds Teaching Hospitals NHS Trust had pre-operative NLR calculated. Demographic, histopathological and survival data were collected. Tissue microarrays were created and stained to determine the mismatch repair (MMR) protein status of each tumour. Local lymphocytic response to the tumour was assessed and graded.

Results

About 358 patients were eligible. Of these 88 had an NLR ⩾5, which predicted lower overall survival and great

SUBMITTER: Pine JK 

PROVIDER: S-EPMC4506398 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature