Leishmania tarentolae: an alternative approach to the production of monoclonal antibodies to treat emerging viral infections.

ABSTRACT:

Background

Monoclonal antibody therapy has an important role to play as a post-exposure prophylactic and therapeutic for the treatment of viral infections, including emerging infections. For example, several patients of the present Ebola virus outbreak in West Africa were treated with ZMapp, a cocktail of three monoclonal antibodies which are expressed in Nicotiana benthamiana.

Discussion

The majority of monoclonal antibodies in clinical use are expressed in mammalian cell lines which offer native folding and glycosylation of the expressed antibody. Monoclonal antibody expression in vegetal systems offers advantages over expression in mammalian cell lines, including improved potential for scale up and reduced costs. In this paper, I highlight the advantages of an upcoming pr

SUBMITTER: Jones JD 

PROVIDER: S-EPMC4506428 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature