The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.

ABSTRACT: In many systems, including the social amoeba Dictyostelium discoideum, development is often marked by dynamic morphological and transcriptional changes orchestrated by key transcription factors. However, efforts to examine sequential genome-wide changes of gene regulation in developmental processes have been fairly limited. Here we report the developmental regulatory dynamics of GtaC, a GATA-type zinc-finger transcription factor, through the analyses of serial ChIP- and RNA-sequencing data. GtaC is essential for developmental progression, decoding extracellular cAMP pulses during early development and may play a role in mediating cell-type differentiation at later stages. We find that GtaC exhibits temporally distinctive DNA-binding patterns concordant with each developmental stage. We ide

SUBMITTER: Santhanam B 

PROVIDER: S-EPMC4506546 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature