Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study.

ABSTRACT:

Objectives

The purpose of this study is to determine the trajectory of lung function change after exposure cessation to occupational organic dust exposure, and to identify factors that modify improvement.

Methods

The Shanghai Textile Worker Study is a longitudinal study of 447 cotton workers exposed to endotoxin-containing dust and 472 silk workers exposed to non-endotoxin-containing dust. Spirometry was performed at 5-year intervals. Air sampling was performed to estimate individual cumulative exposures. The effect of work cessation on forced expiratory volume in 1 s (FEV1) was modelled using generalised additive mixed effects models to identify the trajectory of FEV1 recovery. Linear mixed effects models incorporating interaction terms were used to identify modifiers of FE

SUBMITTER: Lai PS 

PROVIDER: S-EPMC4506722 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature