The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults.

ABSTRACT: By blocking dopamine and norepinephrine transporters, methylphenidate affects cognitive performance and regional brain activation in healthy individuals as well as those with neuropsychiatric disorders. Resting-state connectivity evaluates the functional integrity of a network of brain regions. Here, we examined how methylphenidate effects resting-state functional connectivity of the dorsal striatum and thalamus, areas each with dense dopaminergic and noradrenergic innervations, as well as global cerebral connectivity. We administered a single, oral dose (45 mg) to 24 healthy adults and compared resting-state connectivity to 24 demographically matched adults who did not receive any medication. The results showed that methylphenidate alters seed-based and global connectivity between the tha

SUBMITTER: Farr OM 

PROVIDER: S-EPMC4506752 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature