Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study.

ABSTRACT:

Aims

It remains unclear whether the high cardiovascular disease (CVD) burden in people with type 2 diabetes (T2D) is associated with genetic variants that contribute to CVD in general populations. Recent studies have examined genetic risk scores of single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies for their cumulative contribution to CVD-related traits. Most analyses combined SNPs associated with a single phenotypic class, e.g., lipids. In the present analysis, we examined a more comprehensive risk score comprised of SNPs associated with a broad range of CVD risk phenotypes.

Methods

The composite risk score was analyzed for potential associations with subclinical CVD, self-reported CVD events, and mortality in 983 T2D-affected individuals o

SUBMITTER: Raffield LM 

PROVIDER: S-EPMC4506855 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature