Unknown

Dataset Information

0

Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.


ABSTRACT: To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognosis in hepatocellular carcinoma (HCC) patients.KIF1B protein and mRNA expression was assessed in HCC and paracarcinomatous (PC) tissues from 68 patients with HCC using Western blot and quantitative real-time reverse transcription-PCR, respectively. Student's t-tests were used to analyze relationships between clinicopathologic parameters and KIF1B expression, the Kaplan-Meier method was used to analyze survival outcomes, and the log-rank test was used to compare survival differences between groups.Mean protein and mRNA levels of KIF1B were similar between HCC and PC tissues. However, HCC tissues with vein invasions had significantly lower KIF1B protein levels compared to those without vein invasions (2.30 ± 0.82 relative units vs 2.77 ± 0.84 relative units, P < 0.05). KIF1B protein levels in HCC tissues from patients with recurrence during the follow-up period were significantly lower than those without recurrence (2.31 ± 0.92 relative units vs 2.80 ± 0.80 relative units, P < 0.05). However, KIF1B protein and mRNA expression in HCC patients was not associated with other clinicopathologic parameters. Ratios of KIF1B mRNA expression in HCC tissues to those in PC tissues were correlated with overall survival (13.5 mo vs 20.0 mo, P < 0.05) and disease-free survival (11.5 mo vs 19.5 mo, P < 0.05).Downregulation of KIF1B in HCC tissues is associated with poor prognosis; additional clinical studies are needed to confirm whether KIF1B can serve as a prognostic marker.

SUBMITTER: Yang SZ 

PROVIDER: S-EPMC4507112 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.

Yang Song-Zhu SZ   Wang Jian-Tao JT   Yu Wei-Wei WW   Liu Qing Q   Wu Yan-Fang YF   Chen Shu-Guang SG  

World journal of gastroenterology 20150701 27


<h4>Aim</h4>To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognosis in hepatocellular carcinoma (HCC) patients.<h4>Methods</h4>KIF1B protein and mRNA expression was assessed in HCC and paracarcinomatous (PC) tissues from 68 patients with HCC using Western blot and quantitative real-time reverse transcription-PCR, respectively. Student's t-tests were used to analyze relationships between clinicopathologic parameters and KIF1B expression, the Kaplan-M  ...[more]

Similar Datasets

| S-EPMC6507468 | biostudies-literature
| S-EPMC5385642 | biostudies-literature
| S-EPMC7291483 | biostudies-literature
| S-EPMC4841105 | biostudies-literature
| S-EPMC2761566 | biostudies-literature
| S-EPMC4741514 | biostudies-literature
| S-EPMC8428262 | biostudies-literature
| S-EPMC6786253 | biostudies-literature